New prevent enlarged prostate treatment
Boston (USA), (EFE) .- The combination of two drugs in a long-term treatment can prevent progression of prostate enlargement, a condition that affects nearly half of men over 50 years. .
A study led by John McConnell, Center of Texas Southwestern Medical Center at Dallas, found that the combination of both drugs is more effective than each of them to prevent benign prostatic hyperplasia, according to an article this week publishes the magazine “New England Journal of Medicine.
Doctors tried for 4 ½ years to 2047 men in 20 U.S. medical centers in whom tested whether the drug finasteride (trade name Proscar), doxazosin (Cardura) or a combination of both could stop the enlargement of the gland and avoid the need for surgery.
The three possibilities, in turn, were compared with a placebo effect.
Manufacturers of composites, Pfizer, New York, and Merck, New Jersey, donated drugs, placebos, and funds for the recruitment and retention of patients in the program.
In the study, which was much longer than similar, they were screened every three months, vital signs, urinary symptoms, urinary flow and drug side effects.
Once a year DREs performed checks, urine, and control in the blood serum prostate specific antigen (PSA, for its acronym in English), which is the most useful test that is currently available for diagnosing adenocarcinomas (cancers) in early, curable prostate cancer.
An enlarged prostate is a gland the size of a walnut, requires surgical intervention to one in four men with moderate symptoms, within three years of detection of the condition.
The compounds known as alpha-blockers "provide some relief but not impede the growth of the prostate.
Another category of drugs called 5-alpha reductase inhibitors may reduce by about 20 percent the size of the prostate but usually take six to twelve months before having an effect, and may reduce sexual desire and cause difficulty in penile erection.
Researchers in the study conducted by McConnell used the alpha blocker doxazosin, which fell by 39 percent the risk of benign enlargement of the prostate in some patients, causing dizziness, fatigue, and low blood pressure.
For its part, the 5-alpha reductase inhibitor used, finasteride, had a similar effect by itself, but the sexual side effects were observed in 10 percent of men who used the compound.
The combined benefits brought two of every three men, the article said, explaining that "the combination also provided the greatest relief of symptoms and improvement in urinary flow rate.
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